CVM Research Projects
The research environment at LMU-CVM provides unique opportunities for developing exciting research projects in a wide range of fields. A selection of current projects is listed below:
- Cancer: Projects in cancer research include a feline fibrosarcoma trial evaluating a Canary Pox vector that contains the gene for feline IL-2, a canine lymphoma trial evaluating a plasmid vector encoding the gene for canine CD20, and an equine melanoma trial evaluating a plasmid vector encoding the gene for human tyrosinase.
Additional research projects are focused on developing improved diagnostics for detection of cancer in animals. This includes enhancement of prognostication techniques to direct targeted therapy.
- Infectious diseases: Leptospirosis research at LMU-CVM is aimed at understanding pathogenesis of disease, ecologic factors, and development of improved diagnostic assays. Current projects on Lyme disease are centered on identifying the molecular interactions between the etiologic agent, Borrelia burgdorferi and its tick vector, Ixodes scapularis.
The members of our parasitology research team are currently investigating various aspects of human and animal parasitic diseases, including toxoplasmosis and dirofilariasis.
- Lipidomics: Our metabolomics facility utilizes a high-resolution mass spectrometry platform to assess lipidomics in health and disease. Several of the ongoing projects include, an exploratory lipidomics evaluation of equine lung surfactant, equine metabolic syndrome, Rhodococcus equi infection in foals, effects of DHA supplementation on equine sperm, evaluation of equine plasma from control and dewormed equines, and NSAID toxicity in felines.
- One Health: The Center for Animal Health in Appalachia (CAHA) conducts research aimed at improving animal and public health throughout the Appalachian region. Among many other activities, CAHA is involved in education and advocacy on animal health and public health issues affecting the Appalachian region. CAHA published its State of Animal Health in Appalachia report in Fall 2015.
- Recurrent Airway Obstruction: Researchers at LMU-CVM are investigating the role of lung surfactants in RAO. Recent studies compared the lung surfactant alterations in diseased versus healthy horses, and in neonatal foals versus adult horses. Current projects are aimed at exploring the composition of equine broncho-alveolar lavage fluid with a goal of identifying biomarkers that could predict susceptibility to respiratory disease.
- Simulation: The use of simulation in veterinary education enables students to learn and practice clinical skills and procedures in a safe, standardized environment, minimizing live animal use and improving welfare. Clinical skills research at LMU-CVM seeks to develop and validate new clinical skills training models, assess the use of skills training models in the veterinary curriculum and investigate factors affecting student performance in the clinical skills laboratory that enhance learning.
- Theriogenology: Ongoing projects are examining the effects of a commercial blood product extender on canine semen morphology and motility. In addition, alternative strategies to extend semen longevity are being investigated.